Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex
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چکیده
منابع مشابه
Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex
Breast cancer is a leading killer of women worldwide. Cyclodextrin-based estrogen receptor-targeting drug-delivery systems represent a promising direction in cancer therapy but have rarely been investigated. To seek new targeting therapies for membrane estrogen receptor-positive breast cancer, an estrogen-anchored cyclodextrin encapsulating a doxorubicin derivative Ada-DOX (CDE1-Ada-DOX) has be...
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Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or lipids, either via non-covalent or covalent links, open a wide range of possibilities for the delivery of active substances. CDs can perform as multifunctionalizable cores to which very diverse (macro)molecules and drugs can be conjugated. Grafting with amphiphilic molecules can lead to nanoassemblies exh...
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Extracting biomedical relations such as drug-drug interaction (DDI) from text is an important task in biomedical NLP. Due to the large number of complex sentences in biomedical literature, researchers have employed some sentence simplification techniques to improve the performance of the relation extraction methods. However, due to difficulty of the task, there is no noteworthy improvement in t...
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Because of their bioadaptability and multi-functional characteristics, cyclodextrins (CDs) are capable of alleviating the undesirable properties of drug molecules in various routes of administration through the formation of inclusion complexes. This article outlines the current application of natural and chemically modified CDs in the design of advanced dosage forms. In an oral drug delivery sy...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2015
ISSN: 1178-2013
DOI: 10.2147/ijn.s82255